Pharmaceutical manufacturers deal with four types or combinations: bulk products, intermediates, active ingredients, and FDA-approved pharmaceuticals. Bulk drugs and intermediates are typically produced by fine chemical companies. Vacuum pumps are used in various applications such as crystallization, distillation, extraction, sublimation, drying, deodorization, degassing, crystallization/vaporization, polymerization, vacuum evaporation, negative pressure filtration, monomer recovery, adsorption/desorption, and material conveying.

Dry

Drying is a cost-effective process with relatively low temperatures. It involves evaporating liquids from solids by reducing the vacuum level, ensuring that biological or active components are not damaged, degraded, or oxidized. Drying of medical/biological products removes solvents and water, with a specific requirement for the final vacuum level in the drying chamber to be below 1 torr. After drying, the remaining material is in granular form and can be compressed into tablets. The reduced moisture content extends the shelf life of the product.

Regeneration/Reactor Drying

The fine chemical, pharmaceutical, and fragrance industries utilize reactors. Vacuum systems are employed to reduce/control reaction temperatures, remove reactants, lower costs, control/improve product quality, and capture products.

Many chemical reactions and applications involve drying pump technology, including pharmaceutical intermediates, neutralization and adsorption chemical reactions, desorption/cracking of hydrocarbons and other chemical products, and compound synthesis.

Distillation
Distillation is the process of separating two or more components with different temperatures, pressures, compositions, and phases. As the distillation column approaches equilibrium, different sections have varying concentrations, allowing separation from the mixture. The distillation column provides the pressure to separate different liquid components by altering vacuum levels and temperatures.

The vacuum system removes non-condensables, water, and light hydrocarbons from the system, allowing the feed to be processed through the distillation column for separation. Gases discharged from the top of the distillation column are condensed, and the liquid returns to the column for further separation. This process is typically used for fatty acids, single-component glycerol hydrochloride, vitamins (A, E), oils, fats, waxes, insecticides, and plasticizers, among others.

Deaeration 

Deaeration refers to the removal of gases dissolved or trapped in liquids or products. Vacuum devices are used to remove gases from liquids, thereby improving their physical properties, enhancing product quality for further processing, and preventing cross-contamination or corrosion.
Crystallization/Evaporation
Crystallization is the process of evaporating and cooling supersaturated liquids to form crystals. These crystals are convenient for transportation, storage, and sale. For this application, our vacuum pumps are the ideal choice, as they can control the evaporation/cooling rate across all pressure ranges and reduce production costs by lowering the liquid's boiling point.